Sodium Bicarbonate Injection 100 ml – Critical Care Solution for Emergency & ICU Use
Sodium Bicarbonate Injection 100 ml is a vital pharmaceutical solution widely used in critical care to manage metabolic acidosis and related conditions. As a leading manufacturer and supplier in Delhi, India, J-Bans ICU Care offers Soda Q 100, our premium Sodium Bicarbonate Injection 100 ml, crafted under strict WHO GMP guidelines to ensure unparalleled quality and safety.
This comprehensive guide covers everything For this Critical Care Injection like, uses and dosage to precautions, side effects, storage, and why J-Bans ICU Care stands out as the best choice for healthcare providers across India. Whether you’re a medical professional in Delhi seeking reliable suppliers or exploring manufacturing partners, discover how Soda Q 100 can enhance your critical care protocols.
Note:- “To be used strictly under physician supervision in ICU settings.”
Understanding Sodium Bicarbonate Injection 100ml
Sodium Bicarbonate Injection, commonly known as baking soda in injectable form, is an alkaline solution containing sodium bicarbonate (NaHCO3) in sterile water for injection for critical care. It acts as a buffering agent to correct acid-base imbalances in the body, making it indispensable in emergency and intensive care units (ICUs). In India, where critical care demands high-quality injectables, products like Soda Q 100 from J-Bans ICU Care are formulated to meet global standards, ensuring rapid onset and efficacy.
This injection is typically available in 100 ml vials, providing a convenient volume for intravenous administration. Manufactured using advanced aseptic techniques, it complies with WHO GMP guidelines, which emphasize sterile processing, quality control, and traceability throughout the supply chain. For healthcare facilities in Delhi and beyond, sourcing from a trusted supplier like J-Bans ICU Care guarantees consistency and reliability.
| Parameter | Specification (Soda Q 100) | Clinical Significance |
|---|---|---|
| Active Ingredient | Sodium Bicarbonate USP | Alkalinizing agent for acidosis correction |
| Concentration | 8.4% (84 mg/ml) | Provides 1 mEq each of Na+ and HCO₃⁻ per ml |
| Volume | 100ml per vial | Optimal for ICU dosing protocols |
| pH Range | 7.0 – 8.5 | Physiologically compatible |
| Osmolarity | Approximately 2000 mOsmol/L | Hypertonic solution requiring careful administration |
Chemical Composition and Mechanism Bicarb
Bicarb works by dissociating into sodium and bicarbonate ions upon administration. The bicarbonate ion combines with hydrogen ions in the blood to form carbonic acid, which then breaks down into water and carbon dioxide, effectively neutralizing excess acidity. This mechanism is crucial in critical care scenarios, as per guidelines from bodies like the Central Drugs Standard Control Organization (CDSCO) in India.
| Component | Description | Role in Formulation |
|---|---|---|
| Sodium Bicarbonate | Active ingredient (usually 8.4% w/v) | Provides alkalizing effect |
| Sterile Water for Injection | Solvent | Ensures sterility and compatibility |
| pH Adjusters (if needed) | Minor additives | Maintains pH between 7.0-8.5 for stability |
As experts in pharmaceutical manufacturing, J-Bans ICU Care adheres to WHO GMP rules, including validated cleaning processes and environmental monitoring, to produce Soda Q 100 without contaminants.
Key Uses of Sodium Bicarbonate Injection 100 ml in Critical Care
The therapeutic applications of sodium bicarbonate injection 100ml extend across multiple critical care scenarios, making it an indispensable component of emergency medicine protocols. Healthcare professionals rely on Soda Q 100 for its consistent quality and reliable therapeutic outcomes in the following clinical situations:
Primary Clinical Indications
1. Metabolic Acidosis Management
Metabolic acidosis represents the most common indication for sodium bicarbonate therapy. When blood pH drops below 7.2 with accompanying low bicarbonate levels, intervention becomes critical to prevent organ dysfunction and cardiovascular collapse.
- Severe Metabolic Acidosis: pH below 7.2 with bicarbonate less than 15 mEq/L
- Diabetic Ketoacidosis (DKA): Selected cases with severe acidemia (pH < 6.9)
- Lactic Acidosis: Associated with sepsis, shock, or tissue hypoperfusion
- Renal Tubular Acidosis: Chronic conditions requiring bicarbonate supplementation
- Hyperkalemia with Acidosis: Temporary measure while definitive treatment is initiated
2. Cardiac Arrest and Resuscitation
During prolonged cardiac arrest, severe acidosis develops rapidly. While not routinely recommended in early resuscitation, sodium bicarbonate injection may be considered in specific scenarios:
- Pre-existing metabolic acidosis before cardiac arrest
- Hyperkalemia-induced cardiac arrest
- Tricyclic antidepressant overdose with wide QRS complexes
- Prolonged resuscitation efforts beyond 10-15 minutes
3. Drug Toxicity and Poisoning
Alkalinization therapy with sodium bicarbonate serves as first-line treatment for specific drug overdoses:
| Toxic Agent | Mechanism | Target pH |
|---|---|---|
| Tricyclic Antidepressants | Reduces drug binding to cardiac sodium channels | 7.45 – 7.55 |
| Salicylates (Aspirin) | Enhances renal excretion through ion trapping | 7.50 – 7.55 |
| Phenobarbital | Increases urinary elimination | 7.50 – 8.00 |
| Methotrexate | Prevents crystallization in renal tubules | > 7.50 |
4. Renal Protection and Urinary Alkalinization
- Tumor Lysis Syndrome: Prevents uric acid crystallization during chemotherapy
- Rhabdomyolysis: Reduces myoglobin precipitation in renal tubules
- Contrast-Induced Nephropathy Prevention: Protective effect in high-risk patients
- Hemoglobinuria Management: Prevents hemoglobin cast formation
Clinical Consideration:
The decision to use sodium bicarbonate injection should be based on arterial blood gas analysis, electrolyte levels, and clinical assessment. Empiric administration without proper laboratory evaluation may lead to complications such as metabolic alkalosis, hypernatremia, or fluid overload.
⚠️ Need Sodium Bicarbonate Injection for ICU or Emergency Use?
When critical care cannot wait, J-Bans ICU Care ensures fast, reliable access to WHO-GMP certified critical care injections.
📞 Call our Critical Care Support Line: +91 8527187932
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🏢 Visit Our Facility: J-Bans ICU Care, 341, Vardhman Plaza, Vasundhara Enclave, Delhi-110096
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Supplying hospitals across Delhi NCR and Pan India.
Dosage and Administration Guidelines
Precise dosing of sodium bicarbonate injection 100ml is critical for achieving therapeutic goals while minimizing potential complications. The following evidence-based protocols guide the administration of Soda Q 100 in various clinical scenarios:
Dosage Calculation Methods
Standard Formula for Bicarbonate Deficit
Bicarbonate Deficit (mEq) = 0.5 × Body Weight (kg) × (Desired HCO₃⁻ – Actual HCO₃⁻)
Note: The factor 0.5 represents the bicarbonate space, which is approximately 50% of body weight in kilograms. This accounts for the distribution of bicarbonate in both extracellular and intracellular compartments.
| Clinical Scenario | Initial Dose | Administration Rate | Monitoring Frequency |
|---|---|---|---|
| Severe Metabolic Acidosis (pH < 7.1) | 50-100 mEq (50-100 ml of Soda Q 100) | Over 5-10 minutes, then reassess | ABG every 15-30 minutes |
| Moderate Metabolic Acidosis (pH 7.1-7.2) | 25-50 mEq (25-50 ml) | Over 30-60 minutes | ABG every 1-2 hours |
| Cardiac Arrest | 1 mEq/kg (1 ml/kg of Soda Q 100) | Rapid IV push | After each dose cycle |
| Hyperkalemia (Emergency) | 50 mEq (50 ml) | Over 5 minutes | ECG continuous, K+ every 30 min |
| Urinary Alkalinization | 150 mEq in 1L D5W | 150-250 ml/hour to maintain urine pH 7-8 | Urine pH every 1-2 hours |
Pediatric Dosing Considerations
For pediatric patients, weight-based dosing ensures safety and efficacy:
- Neonates and Infants: 1-2 mEq/kg (1-2 ml/kg) administered slowly over 30-60 minutes
- Children: 1 mEq/kg (1 ml/kg) initially, followed by 0.5 mEq/kg every 10 minutes during resuscitation
- Maximum Rate: Should not exceed 1 mEq/kg/hour in non-emergency situations
- Dilution Required: For neonates, dilute to 4.2% (0.5 mEq/ml) to reduce osmotic load
dministration Techniques for Soda Q 100
Intravenous Push Administration
- Verify Patency: Ensure IV line is patent and functioning properly
- Avoid Extravasation: Sodium bicarbonate injection is highly alkaline and can cause tissue necrosis if infiltrated
- Flush Adequately: Use normal saline before and after administration to prevent drug incompatibilities
- Rate Control: Even in emergencies, avoid exceeding 1 mEq/kg/minute to prevent complications
Continuous Infusion Protocol
- Dilution: Add calculated dose of Soda Q 100 to appropriate volume of D5W or normal saline
- Concentration: Typically 150 mEq in 1000ml (target concentration approximately 150 mEq/L)
- Infusion Rate: Adjust to maintain target pH without exceeding 1 mEq/kg/hour
- Use Dedicated Line: Administer through separate IV line when possible due to compatibility issues
Critical Administration Warnings:
- Never administer undiluted to neonates – risk of intracranial hemorrhage from hyperosmolarity
- Avoid mixing with calcium-containing solutions – risk of precipitation
- Do not add to parenteral nutrition solutions
- Monitor injection site continuously – extravasation causes severe tissue damage
- Rapid administration may cause paradoxical CNS acidosis
Precautions and Warnings When Using Sodium Bicarbonate Injection
While using this critical care injection its safe when used appropriately, precautions are essential to mitigate risks. As a top supplier in Delhi, J-Bans ICU Care emphasizes education on these aspects for all our distributions.
Absolute Contraindications
- Metabolic or Respiratory Alkalosis: Further alkalinization can precipitate tetany, seizures, or cardiac arrhythmias
- Hypocalcemia: Alkalosis reduces ionized calcium levels, potentially triggering severe hypocalcemic crisis
- Severe Pulmonary Edema: Sodium load may worsen fluid overload and respiratory compromise
- Hypernatremia: Additional sodium administration can lead to dangerous sodium levels
- Known Hypersensitivity: Although rare, allergic reactions to sodium bicarbonate have been reported
Relative Contraindications and Special Populations
| Condition | Concern | Management Strategy |
|---|---|---|
| Congestive Heart Failure | Sodium and fluid overload | Use lowest effective dose, monitor fluid balance closely, consider diuretic co-administration |
| Renal Insufficiency | Reduced bicarbonate clearance, sodium retention | Reduce dose by 50%, extend dosing intervals, monitor closely |
| Hypertension | Sodium load may elevate blood pressure | Monitor BP frequently, adjust antihypertensive therapy |
| Pregnancy | Limited safety data (Category C) | Use only if clearly needed, benefits outweigh risks |
| Edematous States | Worsening of edema | Careful fluid balance monitoring, restrict sodium intake |
Special Monitoring Requirements
When administering sodium bicarbonate injection, comprehensive monitoring ensures optimal outcomes and early detection of complications:
- Arterial Blood Gas (ABG): Essential for pH, PCO₂, and bicarbonate monitoring
- Baseline before initiation
- Every 15-30 minutes during acute correction
- Every 1-2 hours during maintenance therapy
- Electrolytes Panel: Assess sodium, potassium, chloride, calcium
- Baseline and after each dose in critical situations
- Every 4-6 hours during continuous infusion
- Fluid Balance: Strict intake and output monitoring to detect fluid overload
- Cardiac Monitoring: Continuous ECG for arrhythmia detection, especially in hyperkalemia treatment
- Neurological Assessment: Watch for signs of cerebral edema or alkalosis-induced confusion
- Urine pH: When using for alkalinization therapy, maintain target pH 7.0-8.0
Drug Interactions Requiring Attention:
- Corticosteroids: Increased sodium retention and potassium loss
- Lithium: Alkalinization increases renal lithium excretion, may require dose adjustment
- Salicylates: Alkalinization enhances elimination but monitor carefully
- Amphetamines: Alkaline urine reduces excretion, prolonging effects
- Quinidine: Reduced renal elimination in alkaline urine
- Ephedrine and Pseudoephedrine: Decreased urinary excretion
Adhering to WHO GMP manufacturing rules, Soda Q 100 from J-Bans ICU Care includes tamper-evident packaging to prevent misuse. For critical care experts in India, these precautions align with national pharmacovigilance programs.
Potential Side Effects of Sodium Bicarbonate Injection 100 ml
Understanding the potential adverse effects of sodium bicarbonate injection 100ml enables healthcare providers to implement proactive monitoring and early intervention strategies. Soda Q 100, while generally well-tolerated when administered correctly, can produce various side effects ranging from mild to severe.
Common Side Effects (Occurring in >1% of patients)
| System Affected | Side Effect | Mechanism | Management |
|---|---|---|---|
| Metabolic | Metabolic alkalosis | Excessive bicarbonate administration | Reduce dose, consider acetazolamide in severe cases |
| Electrolyte | Hypokalemia | Intracellular shift of potassium in alkalosis | Monitor K+ closely, supplement as needed |
| Electrolyte | Hypocalcemia | Reduced ionized calcium in alkalosis | Monitor calcium, supplement if symptomatic |
| Electrolyte | Hypernatremia | High sodium content (1 mEq Na+ per ml) | Monitor sodium levels, adjust fluid management |
| Respiratory | Respiratory depression | Alkalosis-induced hypoventilation | Monitor respiratory rate, consider ventilatory support |
Gastrointestinal Effects
- Gastric distension from CO₂ production
- Belching and flatulence (more common with oral formulations)
- Nausea (usually related to rapid administration)
Cardiovascular Manifestations
- Fluid Overload: Particularly in patients with compromised cardiac or renal function
- Edema: Peripheral and pulmonary due to sodium load
- Hypertension: Secondary to sodium retention and volume expansion
- Arrhythmias: Rare, typically related to electrolyte disturbances
Serious Adverse Events
Life-Threatening Complications Requiring Immediate Intervention:
1. Paradoxical Central Nervous System Acidosis
Rapid bicarbonate administration can cause paradoxical CNS acidosis because CO₂ crosses the blood-brain barrier more rapidly than bicarbonate. This leads to decreased CSF pH despite increasing blood pH.
- Signs: Altered mental status, confusion, lethargy progressing to coma
- Prevention: Administer slowly, ensure adequate ventilation
- Treatment: Stop bicarbonate, increase ventilation to eliminate CO₂
2. Severe Hypocalcemia with Tetany
- Symptoms: Carpopedal spasm, paresthesias, positive Chvostek and Trousseau signs
- Risk Factors: Pre-existing hypocalcemia, rapid pH correction
- Treatment: IV calcium gluconate administration
3. Tissue Necrosis from Extravasation
The highly alkaline nature of sodium bicarbonate injection (pH 7.0-8.5) can cause severe local tissue damage.
- Presentation: Pain, erythema, swelling at injection site progressing to ulceration
- Prevention: Verify IV patency, use central line when possible for large doses
- Treatment: Stop infusion immediately, aspirate residual drug, apply warm compresses, surgical consultation if severe
4. Hypervolemia and Pulmonary Edema
- Risk Factors: Heart failure, renal failure, aggressive fluid resuscitation
- Signs: Dyspnea, rales, elevated JVP, peripheral edema
- Management: Diuretics, oxygen therapy, possible dialysis in renal failure
Rare but Reported Adverse Events
- Intracranial hemorrhage in neonates (related to hyperosmolarity and rapid infusion)
- Hepatocellular injury (mechanism unclear, possibly related to sodium overload)
- Anaphylactoid reactions (extremely rare)
- Milk-alkali syndrome (with prolonged use)
Storage and Handling Requirements
Proper storage and handling of Alkalinizing injection for ICU ensures product stability, sterility, and therapeutic efficacy. our ICU-grade bicarbonate formulation is manufactured and packaged to maintain pharmaceutical integrity throughout its shelf life when stored according to WHO guidelines and GMP standards.
Storage Specifications for Soda Q 100
| Parameter | Requirement | Rationale |
|---|---|---|
| Temperature | 20°C to 25°C (68°F to 77°F) | Maintains chemical stability and prevents precipitation |
| Temperature Excursions | 15°C to 30°C permitted | Allows for brief transport variations |
| Light Exposure | Protect from direct sunlight | Prevents photodegradation |
| Container Position | Store vials upright | Prevents contamination of rubber stopper |
| Freezing | Do NOT freeze | Freezing may cause container damage and precipitation |
| Shelf Life | 36 months from manufacture | Guaranteed potency and sterility |
Compliance with WHO GMP Guidelines for Manufacturing and Use
WHO GMP guidelines are the gold standard for pharmaceutical manufacturing, ensuring products like Sodium Bicarbonate Injection 100 ml “a Critical care injection” are safe, effective, and consistent. At J-Bans ICU Care in Delhi, we integrate these rules into every step of producing Soda Q 100.
Key WHO GMP aspects include:
- Aseptic Processing: Sterile filtration and filling in ISO Class 5 cleanrooms to prevent microbial contamination.
- Quality Control: Rigorous testing for pH, osmolality, and endotoxin levels using validated methods.
- Documentation: Full traceability from raw materials to finished product, with batch records audited regularly.
- Facility Design: Segregated areas for manufacturing, packaging, and storage to avoid cross-contamination.
- Personnel Training: Staff certified in GMP practices, emphasizing hygiene and procedural adherence.
These guidelines extend to usage rules, recommending administration only by trained professionals in equipped facilities. As a WHO GMP-certified entity, J-Bans ICU Care positions itself as the premier choice for this critical care injection in India’s critical care sector.
Production Environment Standards
| Parameter | Specification | Monitoring Frequency |
|---|---|---|
| Clean Room Classification | ISO Class 7 (Class 10,000) | Continuous particle counting |
| HEPA Filtration | 99.99% efficiency at 0.3 microns | Annual integrity testing |
| Temperature Control | 20-25°C ± 2°C | Continuous monitoring with alarms |
| Humidity Control | 40-60% RH | Continuous monitoring |
| Differential Pressure | Positive pressure cascade | Real-time monitoring |
| Microbial Monitoring | Action limits per ISO 14644 | Daily surface and air sampling |
Quality Control Testing Protocol
Every batch of Soda Q 100 undergoes comprehensive testing before release:
Chemical and Physical Testing
- Assay (Potency): HPLC analysis confirming 95-105% of labeled amount
- pH Determination: Must be within 7.0-8.5 range
- Osmolarity: Verification of approximately 2000 mOsmol/L
- Particulate Matter: Light obscuration method per USP <788>
- Clarity and Color: Visual and spectrophotometric evaluation
- Specific Gravity: Confirms proper concentration
- Heavy Metals: ICP-MS testing for contaminants
Microbiological Testing
- Sterility Testing: 14-day incubation per USP standards
- Bacterial Endotoxins (LAL Test): Must be < 0.5 EU/ml
- Bioburden Monitoring: During production process validation
- Container Closure Integrity: Leak testing of every batch
Stability Testing Program
Ongoing stability studies ensure Soda Q 100 maintains quality throughout its shelf life:
- Real-Time Stability: Long-term storage at 25°C/60% RH for 36 months
- Accelerated Stability: 40°C/75% RH for 6 months
- Photostability: ICH Q1B guidelines compliance testing
- Testing Schedule: 0, 3, 6, 9, 12, 18, 24, 36 months
- Parameters Monitored: Assay, pH, clarity, sterility, endotoxins
Why Choose J-Bans ICU Care as Your Manufacturer, Distributor, and Supplier in Delhi, India For Sodium Bicarbonate Injection
In the competitive landscape of pharmaceutical manufacturing in Delhi, J-Bans ICU Care – Best Critical Care PCD Company in india excels as the best for Sodium Bicarbonate Injection 100 ml. Our Soda Q 100 embodies excellence through:
- State-of-the-Art Manufacturing: Utilizing advanced ampoule and vial lines compliant with WHO GMP, ensuring sterility and precision.
- Reliable Distribution Network: Pan-India coverage with focus on Delhi, offering timely deliveries and bulk options for hospitals.
- Supplier Advantages: Competitive pricing, customized packaging, and dedicated support for regulatory compliance.
- Proven Track Record: Years of supplying critical care injectables, with zero recalls on Soda Q 100 due to robust quality systems.
- Innovation and Expertise: Led by pharmaceutical experts, we incorporate feedback from Indian ICUs to refine products.
Why is J-Bans ICU Care the best? Our commitment to ethical manufacturing, transparent supply chains, and customer-centric service sets us apart. For healthcare providers in Delhi seeking a trusted partner, Partner with us now for exclusive deals on Soda Q 100.
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Frequently Asked Questions (FAQs) on Sodium Bicarbonate Injection
What is the primary use of this injection in emergencies?
It treats metabolic acidosis quickly. For optimal results, consider Sodium Bicarbonate Injection 8.4% from J-Bans ICU Care, available in Delhi for reliable critical care.
How should the dosage be calculated for adults?
Base it on body weight and base deficit via ABG tests. our ICU-grade bicarbonate formulation offers precise 100 ml vials for easy dosing in Indian hospitals.
Are there any interactions with other medications?
Yes, avoid mixing with calcium solutions. J-Bans ICU Care’s Soda Q 100 includes compatibility guides compliant with WHO GMP.
What side effects might occur after administration?
Common ones include twitching or nausea. Monitor patients; Soda Q 100 minimizes risks through high-purity manufacturing.
How to store this injection properly?
At 20-25°C, away from light. J-Bans ICU Care ensures Soda Q 100’s stability for Delhi’s varying climates.
Is it safe for pediatric use?
Yes, with adjusted doses. Consult guidelines; Soda Q 100 from J-Bans is trusted in Indian pediatric ICUs.
What precautions are needed during infusion?
Slow administration to prevent edema. J-Bans ICU Care provides training resources for safe use of Soda Q 100.
Can it be used for urinary issues?
Yes, for alkalization. Soda Q 100 by J-Bans ICU Care supports urological applications in Delhi facilities.
How does it help in cardiac arrest?
By correcting acidosis during CPR. Choose Soda Q 100 for emergency kits from J-Bans ICU Care.
Are there long-term effects from repeated use?
Possible electrolyte imbalances. Regular monitoring is key; J-Bans ICU Care’s GMP-compliant Sodium Bicarbonate Injection 8.4% reduces such risks.
What manufacturing standards should it meet?
WHO GMP for sterility and quality. J-Bans ICU Care excels in this for Soda Q 100 supplies in India.
Where to source it in urban areas like Delhi?
From certified suppliers. Like us offers direct distribution of our Soda Q 100 for Delhi healthcare needs.
Conclusion
Sodium Bicarbonate Injection 100 ml remains a cornerstone of critical care in India, offering life-saving benefits when sourced from reputable manufacturers like J-Bans ICU Care. Our Soda Q 100 exemplifies quality, adhering to WHO GMP guidelines across manufacturing, distribution, and supply.
Whether managing acidosis in Delhi’s ICUs or seeking a reliable partner, choose J-Bans for expertise and innovation. Don’t compromise on patient care—Get in touch today to procure Soda Q 100 and elevate your critical care standards. With our commitment to excellence, J-Bans ICU Care ensures long-term reliability for healthcare providers nationwide.
